Healthcare San Antonio, TX Pop. 1,434,625

Nurse Practitioner Salary in San Antonio, Texas

The median nurse practitioner salary in San Antonio, TX is $109,449 per year, which is 10% below the national median and 4.3% below the Texas state average.

City Median
$109,449
vs State Avg
$-4,864
vs National
$-12,161
Cost of Living
88%

Nurse Practitioner Pay in San Antonio: What to Expect (2026)

San Antonio offers a median nurse practitioner salary of $109,449, which is $4,864 below the Texas state average of $114,313. Compared to the national median of $121,610, San Antonio pays below the national benchmark for this role.

One of San Antonio's biggest advantages is its low cost of living at 88% of the national average. This means the $109,449 salary stretches further here — equivalent to roughly $124,374 in an average-cost city. This makes San Antonio an attractive option for nurse practitioners seeking strong real-dollar compensation.

The salary range for nurse practitioners in San Antonio spans from $78,390 at the 10th percentile to $151,380 at the 90th percentile — a $72,990 spread. Entry-level professionals start around $81,000, while senior nurse practitioners with 8+ years of experience can earn up to $139,500. As a major metro area with a population of 1,434,625, San Antonio typically offers more job opportunities and employer competition, which can drive salaries higher.

Nurse Practitioner Salary in San Antonio by Experience

In San Antonio, an entry-level nurse practitioner earns around $81,000, while experienced professionals earn up to $139,500 per year. The local cost of living index is 88% of the national average.

Entry Level (0-2 yrs)
$81,000
$-9,000 vs national
Mid Level (3-7 yrs)
$109,800
$-12,200 vs national
Senior Level (8+ yrs)
$139,500
$-15,500 vs national

Salary Percentiles in San Antonio, TX

Percentile San Antonio
10th Percentile $78,390
25th Percentile $93,780
Median (50th) $109,449
75th Percentile $129,150
90th Percentile $151,380

Nurse Practitioner Salary in Other Texas Cities

Austin, TX
$130,123
Pop. 978,908
Dallas, TX
$124,042
Pop. 1,304,379
Houston, TX
$119,178
Pop. 2,304,580
Fort Worth, TX
$114,313
Pop. 918,915

How to Become a Nurse Practitioner in San Antonio

Education

Most nurse practitioner positions require a master's degree. San Antonio and the surrounding Texas area have institutions offering relevant programs.

Key Skills

Advanced AssessmentPharmacologyDiagnosisPatient EducationEMR SystemsClinical Decision-Making

Job Outlook

Nationally, nurse practitioner employment is projected to grow 40% over the next decade (much faster than average). Demand in San Antonio may vary based on local industry and population growth.

Find Nurse Practitioner Jobs in San Antonio

Browse open nurse practitioner positions in San Antonio, TX:

Indeed → LinkedIn → ZipRecruiter → Glassdoor →

Frequently Asked Questions: Nurse Practitioner Salary in San Antonio

How much does a Nurse Practitioner make in San Antonio, TX? ▼
The median nurse practitioner salary in San Antonio, Texas is $109,449 per year, which is 10% below the national median of $121,610. Salaries range from $78,390 (10th percentile) to $151,380 (90th percentile).
How much does a Nurse Practitioner make per hour in San Antonio? ▼
Based on the median annual salary of $109,449, a nurse practitioner in San Antonio earns approximately $53 per hour assuming a standard 2,080-hour work year.
How does San Antonio compare to the Texas state average for nurse practitioner pay? ▼
San Antonio's median nurse practitioner salary of $109,449 is 4.3% below the Texas state average of $114,313. The local cost of living index is 88% of the national average.
What is the cost of living in San Antonio, TX? ▼
San Antonio has a cost of living index of 88% compared to the national average. This means a nurse practitioner salary of $109,449 in San Antonio has more purchasing power than the same salary in an average-cost city.
What qualifications do I need to become a nurse practitioner in San Antonio? ▼
Most nurse practitioner positions in San Antonio require a master's degree. Key skills include Advanced Assessment, Pharmacology, Diagnosis, Patient Education. The job market is projected to grow 40% nationally over the next decade.