Healthcare Greenville, SC Pop. 72,095

Medical Assistant Salary in Greenville, South Carolina

The median medical assistant salary in Greenville, SC is $35,208 per year, which is 8% below the national median and 3.4% above the South Carolina state average.

City Median
$35,208
vs State Avg
+$1,148
vs National
$-3,062
Cost of Living
92%

Medical Assistant Pay in Greenville: What to Expect (2026)

Greenville offers a median medical assistant salary of $35,208, which is $1,148 above the South Carolina state average of $34,060. Compared to the national median of $38,270, Greenville pays below the national benchmark for this role.

Greenville's cost of living is 92% of the national average, meaning salary figures here closely reflect actual purchasing power. This makes direct comparisons to other cities straightforward.

The salary range for medical assistants in Greenville spans from $27,048 at the 10th percentile to $47,840 at the 90th percentile — a $20,792 spread. Entry-level professionals start around $27,600, while senior medical assistants with 8+ years of experience can earn up to $44,160. Greenville is a smaller market (pop. 72,095), which may mean fewer openings but also less competition for available positions.

Medical Assistant Salary in Greenville by Experience

In Greenville, an entry-level medical assistant earns around $27,600, while experienced professionals earn up to $44,160 per year. The local cost of living index is 92% of the national average.

Entry Level (0-2 yrs)
$27,600
$-2,400 vs national
Mid Level (3-7 yrs)
$34,960
$-3,040 vs national
Senior Level (8+ yrs)
$44,160
$-3,840 vs national

Salary Percentiles in Greenville, SC

Percentile Greenville
10th Percentile $27,048
25th Percentile $30,544
Median (50th) $35,208
75th Percentile $41,216
90th Percentile $47,840

Medical Assistant Salary in Other South Carolina Cities

Mount Pleasant, SC
$40,184
Pop. 94,171
Charleston, SC
$38,270
Pop. 150,227
North Charleston, SC
$36,357
Pop. 115,382
Columbia, SC
$34,443
Pop. 131,674

How to Become a Medical Assistant in Greenville

Education

Most medical assistant positions require a postsecondary nondegree award. Greenville and the surrounding South Carolina area have institutions offering relevant programs.

Key Skills

Vital SignsPatient PrepMedical TerminologyEMR SystemsPhlebotomyScheduling

Job Outlook

Nationally, medical assistant employment is projected to grow 14% over the next decade (much faster than average). Demand in Greenville may vary based on local industry and population growth.

Find Medical Assistant Jobs in Greenville

Browse open medical assistant positions in Greenville, SC:

Indeed → LinkedIn → ZipRecruiter → Glassdoor →

Frequently Asked Questions: Medical Assistant Salary in Greenville

How much does a Medical Assistant make in Greenville, SC? ▼
The median medical assistant salary in Greenville, South Carolina is $35,208 per year, which is 8% below the national median of $38,270. Salaries range from $27,048 (10th percentile) to $47,840 (90th percentile).
How much does a Medical Assistant make per hour in Greenville? ▼
Based on the median annual salary of $35,208, a medical assistant in Greenville earns approximately $17 per hour assuming a standard 2,080-hour work year.
How does Greenville compare to the South Carolina state average for medical assistant pay? ▼
Greenville's median medical assistant salary of $35,208 is 3.4% above the South Carolina state average of $34,060. The local cost of living index is 92% of the national average.
What is the cost of living in Greenville, SC? ▼
Greenville has a cost of living index of 92% compared to the national average. This means a medical assistant salary of $35,208 in Greenville has more purchasing power than the same salary in an average-cost city.
What qualifications do I need to become a medical assistant in Greenville? ▼
Most medical assistant positions in Greenville require a postsecondary nondegree award. Key skills include Vital Signs, Patient Prep, Medical Terminology, EMR Systems. The job market is projected to grow 14% nationally over the next decade.