Nurse Practitioner Salary in Missouri
The median nurse practitioner salary in Missouri is $107,017 per year, which is 12% below the national median of $121,610.
Nurse Practitioner Salary Overview in Missouri (2026)
Missouri ranks #42 out of 50 states for nurse practitioner compensation. Nurse Practitioner salaries in Missouri are below the national median, though the lower cost of living can offset the difference. At $107,017 per year, nurse practitioners in Missouri earn $14,593 less than the national median of $121,610.
A key advantage of working in Missouri is its below-average cost of living (88% of the national index). This means the $107,017 salary has the purchasing power of roughly $121,610 in an average-cost area.
The salary spread in Missouri is significant: nurse practitioners at the 10th percentile earn $76,648, while those at the 90th percentile bring home $148,016 — a $71,368 gap that reflects differences in experience, specialization, employer type, and metro area. The highest-paying city in Missouri for this role is Kansas City, where the median reaches $111,881.
Nationally, nurse practitioner employment is projected to grow 40% over the next decade (much faster than average). This strong growth suggests increasing demand and competitive salaries in Missouri and beyond.
Nurse Practitioner Salary in Missouri by Experience
In Missouri, an entry-level nurse practitioner earns around $79,200, while experienced professionals earn up to $136,400 per year. The cost of living index in Missouri is 88% of the national average.
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View Offers You Qualify For →Salary Percentiles in Missouri
| Percentile | MO Salary |
|---|---|
| 10th Percentile | $76,648 |
| 25th Percentile | $91,696 |
| Median (50th) | $107,017 |
| 75th Percentile | $126,280 |
| 90th Percentile | $148,016 |
Nurse Practitioner Salary by City in Missouri
The largest employment areas for nurse practitioners in Missouri include Kansas City, Saint Louis, Springfield, and Columbia. Salaries vary by city based on local cost of living and demand.
How to Become a Nurse Practitioner in Missouri
Education
Most nurse practitioner positions require a master's degree. Missouri has several accredited institutions offering relevant programs.
Key Skills
Job Outlook in Missouri
Nationally, nurse practitioner employment is projected to grow 40% over the next decade (much faster than average). Missouri's demand may vary based on local industry trends.
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