Healthcare Greenville, SC Pop. 72,095

Physician Assistant Salary in Greenville, South Carolina

The median physician assistant salary in Greenville, SC is $115,929 per year, which is 8% below the national median and 3.4% above the South Carolina state average.

City Median
$115,929
vs State Avg
+$3,780
vs National
$-10,081
Cost of Living
92%

Physician Assistant Pay in Greenville: What to Expect (2026)

Greenville offers a median physician assistant salary of $115,929, which is $3,780 above the South Carolina state average of $112,149. Compared to the national median of $126,010, Greenville pays below the national benchmark for this role.

Greenville's cost of living is 92% of the national average, meaning salary figures here closely reflect actual purchasing power. This makes direct comparisons to other cities straightforward.

The salary range for physician assistants in Greenville spans from $77,280 at the 10th percentile to $160,080 at the 90th percentile — a $82,800 spread. Entry-level professionals start around $80,960, while senior physician assistants with 8+ years of experience can earn up to $149,040. Greenville is a smaller market (pop. 72,095), which may mean fewer openings but also less competition for available positions.

Physician Assistant Salary in Greenville by Experience

In Greenville, an entry-level physician assistant earns around $80,960, while experienced professionals earn up to $149,040 per year. The local cost of living index is 92% of the national average.

Entry Level (0-2 yrs)
$80,960
$-7,040 vs national
Mid Level (3-7 yrs)
$115,920
$-10,080 vs national
Senior Level (8+ yrs)
$149,040
$-12,960 vs national

Salary Percentiles in Greenville, SC

Percentile Greenville
10th Percentile $77,280
25th Percentile $97,520
Median (50th) $115,929
75th Percentile $138,920
90th Percentile $160,080

Physician Assistant Salary in Other South Carolina Cities

Mount Pleasant, SC
$132,311
Pop. 94,171
Charleston, SC
$126,010
Pop. 150,227
North Charleston, SC
$119,710
Pop. 115,382
Columbia, SC
$113,409
Pop. 131,674

How to Become a Physician Assistant in Greenville

Education

Most physician assistant positions require a master's degree. Greenville and the surrounding South Carolina area have institutions offering relevant programs.

Key Skills

Clinical AssessmentPharmacologySurgical AssistingPatient CommunicationEMR SystemsDiagnosis

Job Outlook

Nationally, physician assistant employment is projected to grow 28% over the next decade (much faster than average). Demand in Greenville may vary based on local industry and population growth.

Find Physician Assistant Jobs in Greenville

Browse open physician assistant positions in Greenville, SC:

Indeed → LinkedIn → ZipRecruiter → Glassdoor →

Frequently Asked Questions: Physician Assistant Salary in Greenville

How much does a Physician Assistant make in Greenville, SC? ▼
The median physician assistant salary in Greenville, South Carolina is $115,929 per year, which is 8% below the national median of $126,010. Salaries range from $77,280 (10th percentile) to $160,080 (90th percentile).
How much does a Physician Assistant make per hour in Greenville? ▼
Based on the median annual salary of $115,929, a physician assistant in Greenville earns approximately $56 per hour assuming a standard 2,080-hour work year.
How does Greenville compare to the South Carolina state average for physician assistant pay? ▼
Greenville's median physician assistant salary of $115,929 is 3.4% above the South Carolina state average of $112,149. The local cost of living index is 92% of the national average.
What is the cost of living in Greenville, SC? ▼
Greenville has a cost of living index of 92% compared to the national average. This means a physician assistant salary of $115,929 in Greenville has more purchasing power than the same salary in an average-cost city.
What qualifications do I need to become a physician assistant in Greenville? ▼
Most physician assistant positions in Greenville require a master's degree. Key skills include Clinical Assessment, Pharmacology, Surgical Assisting, Patient Communication. The job market is projected to grow 28% nationally over the next decade.