Healthcare Greenville, SC Pop. 72,095

Nurse Practitioner Salary in Greenville, South Carolina

The median nurse practitioner salary in Greenville, SC is $111,881 per year, which is 8% below the national median and 3.4% above the South Carolina state average.

City Median
$111,881
vs State Avg
+$3,648
vs National
$-9,729
Cost of Living
92%

Nurse Practitioner Pay in Greenville: What to Expect (2026)

Greenville offers a median nurse practitioner salary of $111,881, which is $3,648 above the South Carolina state average of $108,233. Compared to the national median of $121,610, Greenville pays below the national benchmark for this role.

Greenville's cost of living is 92% of the national average, meaning salary figures here closely reflect actual purchasing power. This makes direct comparisons to other cities straightforward.

The salary range for nurse practitioners in Greenville spans from $80,132 at the 10th percentile to $154,744 at the 90th percentile — a $74,612 spread. Entry-level professionals start around $82,800, while senior nurse practitioners with 8+ years of experience can earn up to $142,600. Greenville is a smaller market (pop. 72,095), which may mean fewer openings but also less competition for available positions.

Nurse Practitioner Salary in Greenville by Experience

In Greenville, an entry-level nurse practitioner earns around $82,800, while experienced professionals earn up to $142,600 per year. The local cost of living index is 92% of the national average.

Entry Level (0-2 yrs)
$82,800
$-7,200 vs national
Mid Level (3-7 yrs)
$112,240
$-9,760 vs national
Senior Level (8+ yrs)
$142,600
$-12,400 vs national

Salary Percentiles in Greenville, SC

Percentile Greenville
10th Percentile $80,132
25th Percentile $95,864
Median (50th) $111,881
75th Percentile $132,020
90th Percentile $154,744

Nurse Practitioner Salary in Other South Carolina Cities

Mount Pleasant, SC
$127,691
Pop. 94,171
Charleston, SC
$121,610
Pop. 150,227
North Charleston, SC
$115,530
Pop. 115,382
Columbia, SC
$109,449
Pop. 131,674

How to Become a Nurse Practitioner in Greenville

Education

Most nurse practitioner positions require a master's degree. Greenville and the surrounding South Carolina area have institutions offering relevant programs.

Key Skills

Advanced AssessmentPharmacologyDiagnosisPatient EducationEMR SystemsClinical Decision-Making

Job Outlook

Nationally, nurse practitioner employment is projected to grow 40% over the next decade (much faster than average). Demand in Greenville may vary based on local industry and population growth.

Find Nurse Practitioner Jobs in Greenville

Browse open nurse practitioner positions in Greenville, SC:

Indeed → LinkedIn → ZipRecruiter → Glassdoor →

Frequently Asked Questions: Nurse Practitioner Salary in Greenville

How much does a Nurse Practitioner make in Greenville, SC? ▼
The median nurse practitioner salary in Greenville, South Carolina is $111,881 per year, which is 8% below the national median of $121,610. Salaries range from $80,132 (10th percentile) to $154,744 (90th percentile).
How much does a Nurse Practitioner make per hour in Greenville? ▼
Based on the median annual salary of $111,881, a nurse practitioner in Greenville earns approximately $54 per hour assuming a standard 2,080-hour work year.
How does Greenville compare to the South Carolina state average for nurse practitioner pay? ▼
Greenville's median nurse practitioner salary of $111,881 is 3.4% above the South Carolina state average of $108,233. The local cost of living index is 92% of the national average.
What is the cost of living in Greenville, SC? ▼
Greenville has a cost of living index of 92% compared to the national average. This means a nurse practitioner salary of $111,881 in Greenville has more purchasing power than the same salary in an average-cost city.
What qualifications do I need to become a nurse practitioner in Greenville? ▼
Most nurse practitioner positions in Greenville require a master's degree. Key skills include Advanced Assessment, Pharmacology, Diagnosis, Patient Education. The job market is projected to grow 40% nationally over the next decade.