Healthcare Saint Louis, MO Pop. 301,578

Medical Assistant Salary in Saint Louis, Missouri

The median medical assistant salary in Saint Louis, MO is $34,443 per year, which is 10% below the national median and 2.3% above the Missouri state average.

City Median
$34,443
vs State Avg
+$765
vs National
$-3,827
Cost of Living
90%

Medical Assistant Pay in Saint Louis: What to Expect (2026)

Saint Louis offers a median medical assistant salary of $34,443, which is $765 above the Missouri state average of $33,678. Compared to the national median of $38,270, Saint Louis pays below the national benchmark for this role.

Saint Louis's cost of living is 90% of the national average, meaning salary figures here closely reflect actual purchasing power. This makes direct comparisons to other cities straightforward.

The salary range for medical assistants in Saint Louis spans from $26,460 at the 10th percentile to $46,800 at the 90th percentile — a $20,340 spread. Entry-level professionals start around $27,000, while senior medical assistants with 8+ years of experience can earn up to $43,200. With a population of 301,578, Saint Louis is a mid-sized metro with a growing job market.

Medical Assistant Salary in Saint Louis by Experience

In Saint Louis, an entry-level medical assistant earns around $27,000, while experienced professionals earn up to $43,200 per year. The local cost of living index is 90% of the national average.

Entry Level (0-2 yrs)
$27,000
$-3,000 vs national
Mid Level (3-7 yrs)
$34,200
$-3,800 vs national
Senior Level (8+ yrs)
$43,200
$-4,800 vs national

Salary Percentiles in Saint Louis, MO

Percentile Saint Louis
10th Percentile $26,460
25th Percentile $29,880
Median (50th) $34,443
75th Percentile $40,320
90th Percentile $46,800

Medical Assistant Salary in Other Missouri Cities

Kansas City, MO
$35,208
Pop. 508,090
Columbia, MO
$33,678
Pop. 126,254
Independence, MO
$32,530
Pop. 123,011
Springfield, MO
$31,381
Pop. 169,176

How to Become a Medical Assistant in Saint Louis

Education

Most medical assistant positions require a postsecondary nondegree award. Saint Louis and the surrounding Missouri area have institutions offering relevant programs.

Key Skills

Vital SignsPatient PrepMedical TerminologyEMR SystemsPhlebotomyScheduling

Job Outlook

Nationally, medical assistant employment is projected to grow 14% over the next decade (much faster than average). Demand in Saint Louis may vary based on local industry and population growth.

Find Medical Assistant Jobs in Saint Louis

Browse open medical assistant positions in Saint Louis, MO:

Indeed → LinkedIn → ZipRecruiter → Glassdoor →

Frequently Asked Questions: Medical Assistant Salary in Saint Louis

How much does a Medical Assistant make in Saint Louis, MO? ▼
The median medical assistant salary in Saint Louis, Missouri is $34,443 per year, which is 10% below the national median of $38,270. Salaries range from $26,460 (10th percentile) to $46,800 (90th percentile).
How much does a Medical Assistant make per hour in Saint Louis? ▼
Based on the median annual salary of $34,443, a medical assistant in Saint Louis earns approximately $17 per hour assuming a standard 2,080-hour work year.
How does Saint Louis compare to the Missouri state average for medical assistant pay? ▼
Saint Louis's median medical assistant salary of $34,443 is 2.3% above the Missouri state average of $33,678. The local cost of living index is 90% of the national average.
What is the cost of living in Saint Louis, MO? ▼
Saint Louis has a cost of living index of 90% compared to the national average. This means a medical assistant salary of $34,443 in Saint Louis has more purchasing power than the same salary in an average-cost city.
What qualifications do I need to become a medical assistant in Saint Louis? ▼
Most medical assistant positions in Saint Louis require a postsecondary nondegree award. Key skills include Vital Signs, Patient Prep, Medical Terminology, EMR Systems. The job market is projected to grow 14% nationally over the next decade.