Healthcare Saint Louis, MO Pop. 301,578

Registered Nurse Salary in Saint Louis, Missouri

The median registered nurse salary in Saint Louis, MO is $73,098 per year, which is 10% below the national median and 2.3% above the Missouri state average.

City Median
$73,098
vs State Avg
+$1,624
vs National
$-8,122
Cost of Living
90%

Registered Nurse Pay in Saint Louis: What to Expect (2026)

Saint Louis offers a median registered nurse salary of $73,098, which is $1,624 above the Missouri state average of $71,474. Compared to the national median of $81,220, Saint Louis pays below the national benchmark for this role.

Saint Louis's cost of living is 90% of the national average, meaning salary figures here closely reflect actual purchasing power. This makes direct comparisons to other cities straightforward.

The salary range for registered nurses in Saint Louis spans from $51,660 at the 10th percentile to $108,720 at the 90th percentile — a $57,060 spread. Entry-level professionals start around $52,200, while senior registered nurses with 8+ years of experience can earn up to $103,500. With a population of 301,578, Saint Louis is a mid-sized metro with a growing job market.

Registered Nurse Salary in Saint Louis by Experience

In Saint Louis, an entry-level registered nurse earns around $52,200, while experienced professionals earn up to $103,500 per year. The local cost of living index is 90% of the national average.

Entry Level (0-2 yrs)
$52,200
$-5,800 vs national
Mid Level (3-7 yrs)
$73,800
$-8,200 vs national
Senior Level (8+ yrs)
$103,500
$-11,500 vs national

Salary Percentiles in Saint Louis, MO

Percentile Saint Louis
10th Percentile $51,660
25th Percentile $60,120
Median (50th) $73,098
75th Percentile $90,990
90th Percentile $108,720

Registered Nurse Salary in Other Missouri Cities

Kansas City, MO
$74,722
Pop. 508,090
Columbia, MO
$71,474
Pop. 126,254
Independence, MO
$69,037
Pop. 123,011
Springfield, MO
$66,600
Pop. 169,176

How to Become a Registered Nurse in Saint Louis

Education

Most registered nurse positions require a bachelor's degree. Saint Louis and the surrounding Missouri area have institutions offering relevant programs.

Key Skills

Patient AssessmentMedication AdministrationCritical ThinkingCommunicationEMR SystemsBLS/ACLS

Job Outlook

Nationally, registered nurse employment is projected to grow 6% over the next decade (faster than average). Demand in Saint Louis may vary based on local industry and population growth.

Find Registered Nurse Jobs in Saint Louis

Browse open registered nurse positions in Saint Louis, MO:

Indeed → LinkedIn → ZipRecruiter → Glassdoor →

Frequently Asked Questions: Registered Nurse Salary in Saint Louis

How much does a Registered Nurse make in Saint Louis, MO? ▼
The median registered nurse salary in Saint Louis, Missouri is $73,098 per year, which is 10% below the national median of $81,220. Salaries range from $51,660 (10th percentile) to $108,720 (90th percentile).
How much does a Registered Nurse make per hour in Saint Louis? ▼
Based on the median annual salary of $73,098, a registered nurse in Saint Louis earns approximately $35 per hour assuming a standard 2,080-hour work year.
How does Saint Louis compare to the Missouri state average for registered nurse pay? ▼
Saint Louis's median registered nurse salary of $73,098 is 2.3% above the Missouri state average of $71,474. The local cost of living index is 90% of the national average.
What is the cost of living in Saint Louis, MO? ▼
Saint Louis has a cost of living index of 90% compared to the national average. This means a registered nurse salary of $73,098 in Saint Louis has more purchasing power than the same salary in an average-cost city.
What qualifications do I need to become a registered nurse in Saint Louis? ▼
Most registered nurse positions in Saint Louis require a bachelor's degree. Key skills include Patient Assessment, Medication Administration, Critical Thinking, Communication. The job market is projected to grow 6% nationally over the next decade.