Nurse Practitioner Salary in South Carolina
The median nurse practitioner salary in South Carolina is $108,233 per year, which is 11% below the national median of $121,610.
Nurse Practitioner Salary Overview in South Carolina (2026)
South Carolina ranks #41 out of 50 states for nurse practitioner compensation. Nurse Practitioner salaries in South Carolina are below the national median, though the lower cost of living can offset the difference. At $108,233 per year, nurse practitioners in South Carolina earn $13,377 less than the national median of $121,610.
A key advantage of working in South Carolina is its below-average cost of living (89% of the national index). This means the $108,233 salary has the purchasing power of roughly $121,610 in an average-cost area.
The salary spread in South Carolina is significant: nurse practitioners at the 10th percentile earn $77,519, while those at the 90th percentile bring home $149,698 — a $72,179 gap that reflects differences in experience, specialization, employer type, and metro area. The highest-paying city in South Carolina for this role is Mount Pleasant, where the median reaches $127,691.
Nationally, nurse practitioner employment is projected to grow 40% over the next decade (much faster than average). This strong growth suggests increasing demand and competitive salaries in South Carolina and beyond.
Nurse Practitioner Salary in South Carolina by Experience
In South Carolina, an entry-level nurse practitioner earns around $80,100, while experienced professionals earn up to $137,950 per year. The cost of living index in South Carolina is 89% of the national average.
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View Offers You Qualify For →Salary Percentiles in South Carolina
| Percentile | SC Salary |
|---|---|
| 10th Percentile | $77,519 |
| 25th Percentile | $92,738 |
| Median (50th) | $108,233 |
| 75th Percentile | $127,715 |
| 90th Percentile | $149,698 |
Nurse Practitioner Salary by City in South Carolina
The largest employment areas for nurse practitioners in South Carolina include Charleston, Columbia, Greenville, and North Charleston. Salaries vary by city based on local cost of living and demand.
How to Become a Nurse Practitioner in South Carolina
Education
Most nurse practitioner positions require a master's degree. South Carolina has several accredited institutions offering relevant programs.
Key Skills
Job Outlook in South Carolina
Nationally, nurse practitioner employment is projected to grow 40% over the next decade (much faster than average). South Carolina's demand may vary based on local industry trends.
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