Nurse Practitioner Salary in Sioux Falls, SD: $111,881 (2026)

Nurse Practitioner Pay in Sioux Falls: What to Expect (2026)

Sioux Falls offers a median nurse practitioner salary of $111,881, which is $4,864 above the South Dakota state average of $107,017. Compared to the national median of $121,610, Sioux Falls pays below the national benchmark for this role.

Sioux Falls's cost of living is 92% of the national average, meaning salary figures here closely reflect actual purchasing power. This makes direct comparisons to other cities straightforward.

The salary range for nurse practitioners in Sioux Falls spans from $80,132 at the 10th percentile to $154,744 at the 90th percentile — a $74,612 spread. Entry-level professionals start around $82,800, while senior nurse practitioners with 8+ years of experience can earn up to $142,600. With a population of 192,517, Sioux Falls is a mid-sized metro with a growing job market.

Nurse Practitioner Salary in Sioux Falls by Experience

In Sioux Falls, an entry-level nurse practitioner earns around $82,800, while experienced professionals earn up to $142,600 per year. The local cost of living index is 92% of the national average.

Entry Level (0-2 yrs)

$82,800

$-7,200 vs national

Mid Level (3-7 yrs)

$112,240

$-9,760 vs national

Senior Level (8+ yrs)

$142,600

$-12,400 vs national

Percentile	Sioux Falls	SD State	National
10th Percentile	$80,132	$76,648	$87,100
25th Percentile	$95,864	$91,696	$104,200
Median (50th)	$111,881	$107,017	$121,610
75th Percentile	$132,020	$126,280	$143,500
90th Percentile	$154,744	$148,016	$168,200

Percentile

Sioux Falls

10th Percentile

$80,132

25th Percentile

$95,864

Median (50th)

$111,881

75th Percentile

$132,020

90th Percentile

$154,744

How to Become a Nurse Practitioner in Sioux Falls

Education

Most nurse practitioner positions require a master's degree. Sioux Falls and the surrounding South Dakota area have institutions offering relevant programs.

Key Skills

Advanced AssessmentPharmacologyDiagnosisPatient EducationEMR SystemsClinical Decision-Making

Job Outlook

Nationally, nurse practitioner employment is projected to grow 40% over the next decade (much faster than average). Demand in Sioux Falls may vary based on local industry and population growth.

Frequently Asked Questions: Nurse Practitioner Salary in Sioux Falls

How much does a Nurse Practitioner make in Sioux Falls, SD? ▼

The median nurse practitioner salary in Sioux Falls, South Dakota is $111,881 per year, which is 8% below the national median of $121,610. Salaries range from $80,132 (10th percentile) to $154,744 (90th percentile).

How much does a Nurse Practitioner make per hour in Sioux Falls? ▼

Based on the median annual salary of $111,881, a nurse practitioner in Sioux Falls earns approximately $54 per hour assuming a standard 2,080-hour work year.

How does Sioux Falls compare to the South Dakota state average for nurse practitioner pay? ▼

Sioux Falls's median nurse practitioner salary of $111,881 is 4.5% above the South Dakota state average of $107,017. The local cost of living index is 92% of the national average.

What is the cost of living in Sioux Falls, SD? ▼

Sioux Falls has a cost of living index of 92% compared to the national average. This means a nurse practitioner salary of $111,881 in Sioux Falls has more purchasing power than the same salary in an average-cost city.

What qualifications do I need to become a nurse practitioner in Sioux Falls? ▼

Most nurse practitioner positions in Sioux Falls require a master's degree. Key skills include Advanced Assessment, Pharmacology, Diagnosis, Patient Education. The job market is projected to grow 40% nationally over the next decade.

Nurse Practitioner Salary in Sioux Falls, South Dakota