Healthcare Sioux Falls, SD Pop. 192,517

Registered Nurse Salary in Sioux Falls, South Dakota

The median registered nurse salary in Sioux Falls, SD is $74,722 per year, which is 8% below the national median and 4.5% above the South Dakota state average.

City Median
$74,722
vs State Avg
+$3,248
vs National
$-6,498
Cost of Living
92%

Registered Nurse Pay in Sioux Falls: What to Expect (2026)

Sioux Falls offers a median registered nurse salary of $74,722, which is $3,248 above the South Dakota state average of $71,474. Compared to the national median of $81,220, Sioux Falls pays below the national benchmark for this role.

Sioux Falls's cost of living is 92% of the national average, meaning salary figures here closely reflect actual purchasing power. This makes direct comparisons to other cities straightforward.

The salary range for registered nurses in Sioux Falls spans from $52,808 at the 10th percentile to $111,136 at the 90th percentile — a $58,328 spread. Entry-level professionals start around $53,360, while senior registered nurses with 8+ years of experience can earn up to $105,800. With a population of 192,517, Sioux Falls is a mid-sized metro with a growing job market.

Registered Nurse Salary in Sioux Falls by Experience

In Sioux Falls, an entry-level registered nurse earns around $53,360, while experienced professionals earn up to $105,800 per year. The local cost of living index is 92% of the national average.

Entry Level (0-2 yrs)
$53,360
$-4,640 vs national
Mid Level (3-7 yrs)
$75,440
$-6,560 vs national
Senior Level (8+ yrs)
$105,800
$-9,200 vs national

Salary Percentiles in Sioux Falls, SD

Percentile Sioux Falls
10th Percentile $52,808
25th Percentile $61,456
Median (50th) $74,722
75th Percentile $93,012
90th Percentile $111,136

Registered Nurse Salary in Other South Dakota Cities

How to Become a Registered Nurse in Sioux Falls

Education

Most registered nurse positions require a bachelor's degree. Sioux Falls and the surrounding South Dakota area have institutions offering relevant programs.

Key Skills

Patient AssessmentMedication AdministrationCritical ThinkingCommunicationEMR SystemsBLS/ACLS

Job Outlook

Nationally, registered nurse employment is projected to grow 6% over the next decade (faster than average). Demand in Sioux Falls may vary based on local industry and population growth.

Find Registered Nurse Jobs in Sioux Falls

Browse open registered nurse positions in Sioux Falls, SD:

Frequently Asked Questions: Registered Nurse Salary in Sioux Falls

How much does a Registered Nurse make in Sioux Falls, SD? ▼
The median registered nurse salary in Sioux Falls, South Dakota is $74,722 per year, which is 8% below the national median of $81,220. Salaries range from $52,808 (10th percentile) to $111,136 (90th percentile).
How much does a Registered Nurse make per hour in Sioux Falls? ▼
Based on the median annual salary of $74,722, a registered nurse in Sioux Falls earns approximately $36 per hour assuming a standard 2,080-hour work year.
How does Sioux Falls compare to the South Dakota state average for registered nurse pay? ▼
Sioux Falls's median registered nurse salary of $74,722 is 4.5% above the South Dakota state average of $71,474. The local cost of living index is 92% of the national average.
What is the cost of living in Sioux Falls, SD? ▼
Sioux Falls has a cost of living index of 92% compared to the national average. This means a registered nurse salary of $74,722 in Sioux Falls has more purchasing power than the same salary in an average-cost city.
What qualifications do I need to become a registered nurse in Sioux Falls? ▼
Most registered nurse positions in Sioux Falls require a bachelor's degree. Key skills include Patient Assessment, Medication Administration, Critical Thinking, Communication. The job market is projected to grow 6% nationally over the next decade.