Healthcare Saint Louis, MO Pop. 301,578

Physician Assistant Salary in Saint Louis, Missouri

The median physician assistant salary in Saint Louis, MO is $113,409 per year, which is 10% below the national median and 2.3% above the Missouri state average.

City Median
$113,409
vs State Avg
+$2,520
vs National
$-12,601
Cost of Living
90%

Physician Assistant Pay in Saint Louis: What to Expect (2026)

Saint Louis offers a median physician assistant salary of $113,409, which is $2,520 above the Missouri state average of $110,889. Compared to the national median of $126,010, Saint Louis pays below the national benchmark for this role.

Saint Louis's cost of living is 90% of the national average, meaning salary figures here closely reflect actual purchasing power. This makes direct comparisons to other cities straightforward.

The salary range for physician assistants in Saint Louis spans from $75,600 at the 10th percentile to $156,600 at the 90th percentile — a $81,000 spread. Entry-level professionals start around $79,200, while senior physician assistants with 8+ years of experience can earn up to $145,800. With a population of 301,578, Saint Louis is a mid-sized metro with a growing job market.

Physician Assistant Salary in Saint Louis by Experience

In Saint Louis, an entry-level physician assistant earns around $79,200, while experienced professionals earn up to $145,800 per year. The local cost of living index is 90% of the national average.

Entry Level (0-2 yrs)
$79,200
$-8,800 vs national
Mid Level (3-7 yrs)
$113,400
$-12,600 vs national
Senior Level (8+ yrs)
$145,800
$-16,200 vs national

Salary Percentiles in Saint Louis, MO

Percentile Saint Louis
10th Percentile $75,600
25th Percentile $95,400
Median (50th) $113,409
75th Percentile $135,900
90th Percentile $156,600

Physician Assistant Salary in Other Missouri Cities

Kansas City, MO
$115,929
Pop. 508,090
Columbia, MO
$110,889
Pop. 126,254
Independence, MO
$107,109
Pop. 123,011
Springfield, MO
$103,328
Pop. 169,176

How to Become a Physician Assistant in Saint Louis

Education

Most physician assistant positions require a master's degree. Saint Louis and the surrounding Missouri area have institutions offering relevant programs.

Key Skills

Clinical AssessmentPharmacologySurgical AssistingPatient CommunicationEMR SystemsDiagnosis

Job Outlook

Nationally, physician assistant employment is projected to grow 28% over the next decade (much faster than average). Demand in Saint Louis may vary based on local industry and population growth.

Find Physician Assistant Jobs in Saint Louis

Browse open physician assistant positions in Saint Louis, MO:

Indeed → LinkedIn → ZipRecruiter → Glassdoor →

Frequently Asked Questions: Physician Assistant Salary in Saint Louis

How much does a Physician Assistant make in Saint Louis, MO? ▼
The median physician assistant salary in Saint Louis, Missouri is $113,409 per year, which is 10% below the national median of $126,010. Salaries range from $75,600 (10th percentile) to $156,600 (90th percentile).
How much does a Physician Assistant make per hour in Saint Louis? ▼
Based on the median annual salary of $113,409, a physician assistant in Saint Louis earns approximately $55 per hour assuming a standard 2,080-hour work year.
How does Saint Louis compare to the Missouri state average for physician assistant pay? ▼
Saint Louis's median physician assistant salary of $113,409 is 2.3% above the Missouri state average of $110,889. The local cost of living index is 90% of the national average.
What is the cost of living in Saint Louis, MO? ▼
Saint Louis has a cost of living index of 90% compared to the national average. This means a physician assistant salary of $113,409 in Saint Louis has more purchasing power than the same salary in an average-cost city.
What qualifications do I need to become a physician assistant in Saint Louis? ▼
Most physician assistant positions in Saint Louis require a master's degree. Key skills include Clinical Assessment, Pharmacology, Surgical Assisting, Patient Communication. The job market is projected to grow 28% nationally over the next decade.