Registered Nurse Salary in South Carolina
The median registered nurse salary in South Carolina is $72,286 per year, which is 11% below the national median of $81,220.
Registered Nurse Salary Overview in South Carolina (2026)
South Carolina ranks #41 out of 50 states for registered nurse compensation. Registered Nurse salaries in South Carolina are below the national median, though the lower cost of living can offset the difference. At $72,286 per year, registered nurses in South Carolina earn $8,934 less than the national median of $81,220.
A key advantage of working in South Carolina is its below-average cost of living (89% of the national index). This means the $72,286 salary has the purchasing power of roughly $81,220 in an average-cost area.
The salary spread in South Carolina is significant: registered nurses at the 10th percentile earn $51,086, while those at the 90th percentile bring home $107,512 — a $56,426 gap that reflects differences in experience, specialization, employer type, and metro area. The highest-paying city in South Carolina for this role is Mount Pleasant, where the median reaches $85,281.
Nationally, registered nurse employment is projected to grow 6% over the next decade (faster than average). This steady growth indicates stable demand for registered nurses across the country.
Registered Nurse Salary in South Carolina by Experience
In South Carolina, an entry-level registered nurse earns around $51,620, while experienced professionals earn up to $102,350 per year. The cost of living index in South Carolina is 89% of the national average.
Build Wealth on Your Income
With a $72,286 income, financial advisors recommend investing 15–20% annually. Start building a diversified portfolio with as little as $10.
See Investment Options →Salary Percentiles in South Carolina
| Percentile | SC Salary |
|---|---|
| 10th Percentile | $51,086 |
| 25th Percentile | $59,452 |
| Median (50th) | $72,286 |
| 75th Percentile | $89,979 |
| 90th Percentile | $107,512 |
Registered Nurse Salary by City in South Carolina
The largest employment areas for registered nurses in South Carolina include Charleston, Columbia, Greenville, and North Charleston. Salaries vary by city based on local cost of living and demand.
How to Become a Registered Nurse in South Carolina
Education
Most registered nurse positions require a bachelor's degree. South Carolina has several accredited institutions offering relevant programs.
Key Skills
Job Outlook in South Carolina
Nationally, registered nurse employment is projected to grow 6% over the next decade (faster than average). South Carolina's demand may vary based on local industry trends.
Negotiate Your Way to Senior Pay
Data shows Registered Nurses who negotiate earn 7–15% more. A single negotiation could add $30,064 over your career trajectory.
Get Negotiation Scripts — $197 →Open to Registered Nurse Roles in South Carolina?
Get matched with recruiters hiring registered nurses in South Carolina at competitive salaries.
Or browse positions directly: